The overall purpose of the CORD-CHD trial is to find the best timing of umbilical cord clamping in neonates born with congenital heart disease. Recently, evidence has emerged on the health benefits of longer delays (waiting ~2 minutes) before umbilical cord clamping; however, neonates with congenital heart disease have not been included in large, multi-center studies. This trial will compare umbilical cord clamping at 120 seconds vs. umbilical cord clamping at 30 seconds on postnatal and neurodevelopmental outcomes of neonates with congenital heart disease. The proposed trial has the potential to have a major impact on umbilical cord management among a highly vulnerable population.
Project Overview:
CORD-CHD is a multi-center randomized clinical trial being conducted at multiple hospitals across the United States and Canada. The trial is comparing umbilical cord clamping at 120 seconds vs. umbilical cord clamping at 30 seconds in 500 neonates born with congenital heart disease. Outcomes include short-term postnatal and two-year neurodevelopmental outcomes.